Depression has been examined from a Western, Asian American and Indian American- cultural, specific point of view. The purpose of this paper was to examine if the DSM can be used as a multicultural diagnostic tool for depression. Research suggests that ethnic and racial minority groups are often underserved by the mental health system (Snowden, 1996; Lewis-Fernàndez & Kleinman, 1994). Language, social construction, family, age, gender and religion have all been found to be barriers to treatment among different cultures (Blackmore, 1998; Ramisetty-Mikler, 1993). After reviewing the literature a strong argument can be made for the DSM being used as a multicultural diagnostic tool, as long as clinicians have the appropriate understanding of different cultures and their belief systems.